Dopamine causes inhibition of Na+-K+-ATPase activity in rat proximal convoluted tubule segments.

@article{Aperia1987DopamineCI,
  title={Dopamine causes inhibition of Na+-K+-ATPase activity in rat proximal convoluted tubule segments.},
  author={Anita C. Aperia and Alejandro Mario Bertorello and Istvan Seri},
  journal={The American journal of physiology},
  year={1987},
  volume={252 1 Pt 2},
  pages={F39-45}
}
We studied the effect of dopamine (DA) on Na+-K+-ATPase activity in proximal convoluted tubule (PCT) segments dissected from perfused rat kidneys. DA inhibited Na+-K+-ATPase activity in a dose-dependent manner. Inhibition was significant with 10(-7) M DA and maximal with 10(-4) M DA. The inhibition was reversible. Enzyme inhibition occurred in the presence of DA and a DA antagonist, metoclopramide, but not when 10(5) M of the DA1 and DA2 agonists fenoldopam mesylate and LY 171555 were added in… CONTINUE READING