Dopamine blocking activity of clomipramine in patients with obsessive-compulsive disorder

@article{Austin1991DopamineBA,
  title={Dopamine blocking activity of clomipramine in patients with obsessive-compulsive disorder},
  author={L. Austin and R. Lydiard and J. Ballenger and B. Cohen and E. Ellinwood},
  journal={Biological Psychiatry},
  year={1991},
  volume={30},
  pages={225-232}
}
  • L. Austin, R. Lydiard, +2 authors E. Ellinwood
  • Published 1991
  • Psychology, Medicine
  • Biological Psychiatry
  • While many data suggest that Obsessive-Compulsive Disorder (OCD) is an illness accompanied by dysregulation of the serotonergic system, interesting clinical evidence and animal studies also suggest possible dysregulation of the dopaminergic (DA) system. In order to determine whether clomipramine (CMI), an antiobsessional agent, is capable of altering DA function, we performed a neuroleptic radioreceptor assay (NRRA) on plasma samples from OCD patients before and after treatment in a double… CONTINUE READING
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