Dopamine-beta-hydroxylase in postural tachycardia syndrome.

  title={Dopamine-beta-hydroxylase in postural tachycardia syndrome.},
  author={Emily M. Garland and Bonnie K. Black and Paul A. Harris and David P. Robertson},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={293 1},
Norepinephrine is frequently elevated in postural tachycardia syndrome (POTS), a syndrome of heterogeneous etiology characterized by a >30 beats/min increase in heart rate with standing. Norepinephrine is synthesized from dopamine by dopamine-beta-hydroxylase (DBH). The results of a preliminary study suggested that the T allele frequency of the DBH -1021C-->T polymorphism is elevated in POTS. This allele correlates with low DBH activity and might predict reduced serum DBH activity in patients… CONTINUE READING