Dopamine and alcohol relapse: D1 and D2 antagonists increase relapse rates in animal studies and in clinical trials.

@article{Walter2001DopamineAA,
  title={Dopamine and alcohol relapse: D1 and D2 antagonists increase relapse rates in animal studies and in clinical trials.},
  author={Henriette Walter and Katrin Ramskogler and Barbara Semler and Otto Michael Lesch and Werner Platz},
  journal={Journal of biomedical science},
  year={2001},
  volume={8 1},
  pages={83-8}
}
A considerable number of animal studies on the effects of dopaminergic agents on alcohol intake behavior have been performed. Acute alcohol administration in rats induces dopamine release in the caudate nucleus and in the nucleus accumbens, an effect related among others to reinforcement. It has been repeatedly suggested that D1 and D2 receptor activation mediates reward. As alcohol consumption and dopaminergic transmission seem to have a close relationship, all kinds of dopaminergic agents may… CONTINUE READING
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