Dopamine and Stress System Modulation of Sex Differences in Decision Making

  title={Dopamine and Stress System Modulation of Sex Differences in Decision Making},
  author={Polymnia Georgiou and Panos Zanos and Shambhu Bhat and J. Kathleen Tracy and Istv{\'a}n J. Merchenthaler and Margaret M McCarthy and Todd D. Gould},
Maladaptive decision making is associated with several neuropsychiatric disorders, including problem gambling and suicidal behavior. The prevalence of these disorders is higher in men vs women, suggesting gender-dependent regulation of their pathophysiology underpinnings. We assessed sex differences in decision making using the rat version of the Iowa gambling task. Female rats identified the most optimal choice from session 1, whereas male rats from session 5. Male, but not female rats… CONTINUE READING
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