Dopamine and NMDA systems modulate long-term nociception in the rat anterior cingulate cortex.

@article{Lpezvila2004DopamineAN,
  title={Dopamine and NMDA systems modulate long-term nociception in the rat anterior cingulate cortex.},
  author={Alberto L{\'o}pez-{\'A}vila and Ulises Coffeen and J Manuel Ortega-Legaspi and Rosendo del Angel and Francisco Pellicer},
  journal={Pain},
  year={2004},
  volume={111 1-2},
  pages={136-43}
}
The anterior cingulate cortex (ACC) plays a key role in pain processing. It has been reported that increased activity of glutamatergic projections into the ACC intensifies nociception; whereas dopaminergic projections inhibit it. The aim of this study was to evaluate the role of dopaminergic and NMDA systems of the ACC in the modulation of long-term nociception elicited by sciatic denervation in the rat. Score, onset and incidence of long-term nociception were measured by the autotomy behavior… CONTINUE READING