Dopamine and Glutamate Induce Distinct Striatal Splice Forms of Ania-6, an RNA Polymerase II-Associated Cyclin

@article{Berke2001DopamineAG,
  title={Dopamine and Glutamate Induce Distinct Striatal Splice Forms of Ania-6, an RNA Polymerase II-Associated Cyclin},
  author={Joshua D. Berke and V{\'e}ronique Sgambato and P Zhu and Brigitte Lavoie and M. Vincent and Michael Krause and Steven E Hyman},
  journal={Neuron},
  year={2001},
  volume={32},
  pages={277-287}
}
Control of neuronal gene expression by drugs or neurotransmitters is a critical step in long-term neural plasticity. Here, we show that a gene induced in the striatum by cocaine or direct dopamine stimulation, ania-6, is a member of a novel family of cyclins with homology to cyclins K/T/H/C. Further, different types of neurotransmitter stimulation cause selective induction of distinct ania-6 isoforms, through alternative splicing. The longer Ania-6 protein colocalizes with nuclear speckles and… CONTINUE READING