Dopamine and Dobutamine in Pediatric Therapy

@article{BhattMehta1989DopamineAD,
  title={Dopamine and Dobutamine in Pediatric Therapy},
  author={Varsha Bhatt-Mehta and Milap C. Nahata},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={1989},
  volume={9}
}
  • V. Bhatt-Mehta, M. Nahata
  • Published 10 September 1989
  • Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Dopamine hydrochloride is widely used to increase blood pressure, cardiac output, urine output, and peripheral perfusion in neonates, infants, and older children with shock and cardiac failure. Its pharmacologic effects are dose dependent, and at low, intermediate, and high dosages include dilation of renal, mesenteric, and cerebral vasculature; inotropic response in the myocardium; and increases in peripheral and renal vascular resistance, respectively. The inotropic response is diminished in… 
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55 Citations
Highly Influential Citations
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55 Citations

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Citation Type

Pharmacology of inotropic agents in infants and children.
Pharmacology Review: Developmentally Regulated Cardiovascular, Renal, and Neuroendocrine Effects of Dopamine
TLDR
The mechanisms of action and pharmacokinetics of dopamine are reviewed and the cardiovascular, renal, and neuroendocrine effects of the drug are discussed and the clinical evidence supporting and challenging the use of this sympathomimetic amine in the treatment of neonatal cardiovascular compromise is examined.
Circulatory support of the sick preterm infant.
  • I. Seri
  • Medicine
    Seminars in neonatology : SN
  • 2001
TLDR
Management of the critically ill hypotensive preterm infant remains challenging and requires a better understanding of the pathophysiology of neonatal shock and improvements in the ability to evaluate cardiac output, organ blood flow, and tissue perfusion at the bedside.
Pharmacology Review: The Use of Dobutamine in the Treatment of Neonatal Cardiovascular Compromise
TLDR
Evidence that use of dobutamine or the other sympathomimetic amines (dopamine, epinephrine, norepinephrine) improves neonatal mortality or morbidity is only suggestive and indirect.
Cardiovascular impact of dobutamine in neonates with myocardial dysfunction.
Dose-Dependent Hemodynamic and Metabolic Effects of Vasoactive Medications in Normotensive, Anesthetized Neonatal Piglets
TLDR
Novel drug- and dose-specific differences in the hemodynamic response to escalating doses of vasoactive medications in the neonatal cardiovascular system are revealed and information is provided for future clinical studies investigating the use of vasOactive medications for the treatment of Neonatal cardiovascular compromise.
Renal function after cardiopulmonary bypass in children: comparison of dopamine with dobutamine.
TLDR
Low dose dopamine did not appear to be superior to dobutamine for protection of renal function in these patients, and the subgroup of patients in group 1 who underwent periods of CPB in excess of 2 h had persistently greater postoperative serum concentrations of creatinine.
HEMODYNAMIC RESPONSE TO CONTINUOUS INFUSION OF DOBUTAMINE IN ALAGILLE’S SYNDROME
TLDR
The increase in cardiac index, in response to dobutamine in patients with Alagille’s syndrome, is independent of the more conventional measurement of the right ventricular pressure.
Response of hypotensive dogs to dopamine hydrochloride and dobutamine hydrochloride during deep isoflurane anesthesia
TLDR
Dopamine caused significant dose-dependent responses and achieved target MAP and CI at 7 μg/kg/min; dobutamine at 2 μg/ kg/min significantly affected only CI values....
Levels of Catecholamines, Arginine Vasopressin and Atrial Natriuretic Peptide in Hypotensive Extremely Low Birth Weight Infants in the First 24 Hours after Birth
TLDR
ELBWI with SH may have decreased conversion of dopamine to norepinephrine, and this mechanism may contribute to development of SH in ELBWI.
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References

SHOWING 1-10 OF 80 REFERENCES
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TLDR
Given the intrinsically higher heart rate of children, the levels of tachycardia produced by the drug in some instances reach unacceptable levels and as such, may make dobutamine unsuitable for use in children after cardiopulmonary bypass.
The hemodynamic effect of dopamine in children.
Hemodynamic effects of dobutamine in children.
Effects of dopamine on renal functions in premature neonates with respiratory distress syndrome.
TLDR
The observations demonstrate the functional maturity of renal dopaminergic receptors in the preterm infants with RDS and the possible mechanism of the renal changes are discussed.
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TLDR
Because of the more than three-fold prolongation of dopamine clearances in patients with hepatic or renal dysfunction, these patients may be more likely to suffer toxic effects of dopamine at the usual drug infusion rates.
Efficacy of Dopamine, Dobutamine, and Epinephrine During Emergence from Cardiopulmonary Bypass in Man
TLDR
It is concluded that dopamine, epinephrine, and dobutamine all are effective inotropic agents during the immediate post-bypass period, with variations discussed in detail.
Comparative Hemodynamic Effects of Isoproterenol, Dopamine, and Dobutamine in the Newborn Dog
Summary: To compare the hemodynamic effects of isoproterenol, dopamine, and dobutamine in the immature animal, each drug was infused into anesthetized open chest puppies and cardiac output was…
Dobutamine: a hemodynamic evaluation in children with shock.
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