Dopamine agonists in schizophrenia: a review

  title={Dopamine agonists in schizophrenia: a review},
  author={Otto Benkert and Florian M{\"u}ller-Siecheneder and Hermann Wetzel},
  journal={European Neuropsychopharmacology},
Although it is unlikely that the different types of course and severity of schizophrenia are caused by one neurochemical abnormality alone, indirect pharmacological evidence still suggests a relative excess of dopaminergic activity being implicated in the pathogenesis of most of the schizophrenic symptoms, e.g. positive symptomatology. Synthesis and release of dopamine as well as firing rates of dopaminergic neurons are controlled by stimulation of autoreceptors via a negative feedback… CONTINUE READING


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