Dopamine activation of an orphan of the steroid receptor superfamily.

  title={Dopamine activation of an orphan of the steroid receptor superfamily.},
  author={Rhys Power and John P. Lydon and Orla M. Conneely and Bert W O'malley},
  volume={252 5012},
The chicken ovalbumin upstream promoter transcription factor (COUP-TF) is a member of the steroid receptor superfamily and participates in the regulation of several genes. While a number of functions have been ascribed to COUP-TF, no ligand or activator molecule has been identified, and thus it is classified as one of a group of orphan receptors. Activation of COUP-TF by physiological concentrations of the neurotransmitter dopamine was observed in transient transfection assays. Treatment of… CONTINUE READING

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