Dopamine Transporter Binding Is Unaffected by L-DOPA Administration in Normal and MPTP-Treated Monkeys

@inproceedings{Fernagut2010DopamineTB,
  title={Dopamine Transporter Binding Is Unaffected by L-DOPA Administration in Normal and MPTP-Treated Monkeys},
  author={Pierre-Olivier Fernagut and Qin Li and Sandra Dovero and Piu Chan and Tao Wu and Paula Ravenscroft and Michael Hill and Zhenwen Chen and Erwan B{\'e}zard},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Radiotracer imaging of the presynaptic nigrostriatal dopaminergic system is used to assess disease progression in Parkinson's disease (PD) and may provide a useful adjunct to clinical assessment during therapeutic trials of potential neuroprotective agents. Several clinical trials comparing dopamine agonists to L-DOPA or early vs. late L-DOPA have revealed differences between clinical assessment and imaging of the presynaptic dopaminergic system, hence questioning the comparability… CONTINUE READING
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