Dopamine Transporter (DAT) Inhibitors Alleviate Specific Parkinsonian Deficits in Monkeys: Association with DAT Occupancy in Vivo

  title={Dopamine Transporter (DAT) Inhibitors Alleviate Specific Parkinsonian Deficits in Monkeys: Association with DAT Occupancy in Vivo},
  author={B. Madras and M. Fahey and M. Goulet and Zhicheng Lin and J. Bendor and Claudia M. Goodrich and P. Meltzer and D. Elmaleh and E. Livni and A. Bonab and A. Fischman},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={570 - 585}
Viable dopamine neurons in Parkinson's disease express the dopamine transporter (DAT) and release dopamine (DA). We postulated that potent DAT inhibitors, with low affinity for the serotonin transporter (SERT), may elevate endogenously released extracellular dopamine levels to provide therapeutic benefit. The therapeutic potential of eight DAT inhibitors was investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated cynomolgus monkeys (Macaca fascicularis), with efficacy correlated… Expand
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