Dopamine Transporter (DAT) Inhibitors Alleviate Specific Parkinsonian Deficits in Monkeys: Association with DAT Occupancy in Vivo

@article{Madras2006DopamineT,
  title={Dopamine Transporter (DAT) Inhibitors Alleviate Specific Parkinsonian Deficits in Monkeys: Association with DAT Occupancy in Vivo},
  author={B. Madras and M. Fahey and M. Goulet and Zhicheng Lin and J. Bendor and Claudia M. Goodrich and P. Meltzer and D. Elmaleh and E. Livni and A. Bonab and A. Fischman},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2006},
  volume={319},
  pages={570 - 585}
}
Viable dopamine neurons in Parkinson's disease express the dopamine transporter (DAT) and release dopamine (DA). We postulated that potent DAT inhibitors, with low affinity for the serotonin transporter (SERT), may elevate endogenously released extracellular dopamine levels to provide therapeutic benefit. The therapeutic potential of eight DAT inhibitors was investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated cynomolgus monkeys (Macaca fascicularis), with efficacy correlated… Expand
24 Citations
Modafinil Occupies Dopamine and Norepinephrine Transporters in Vivo and Modulates the Transporters and Trace Amine Activity in Vitro
Dopamine transporter imaging with [123I]FP-CIT SPECT: potential effects of drugs
  • J. Booij, P. Kemp
  • Medicine
  • European Journal of Nuclear Medicine and Molecular Imaging
  • 2007
Classic Studies on the Interaction of Cocaine and the Dopamine Transporter
  • V. Verma
  • Medicine
  • Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2015
The noradrenaline transporter as site of action for the anti-Parkinson drug amantadine
2-Substituted 3β-Aryltropane Cocaine Analogs Produce Atypical Effects without Inducing Inward-Facing Dopamine Transporter Conformations
...
1
2
3
...

References

SHOWING 1-10 OF 43 REFERENCES
The dopamine transporter: Importance in Parkinson's disease
Severe depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson's‐diseased striatum
D(1) dopamine receptor agonists are more effective in alleviating advanced than mild parkinsonism in 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated monkeys.
In vivo neurochemical profile of dopamine uptake inhibitors and releasers in rat caudate-putamen.
Rapid detection of Parkinson's disease by SPECT with altropane: A selective ligand for dopamine transporters
Quantification of dopamine transporter density in monkeys by dynamic PET imaging of multiple injections of 11C‐CFT
Bupropion increases striatal vesicular monoamine transport
Dopamine reuptake inhibition and failure to evoke dyskinesia in MPTP-treated primates.
...
1
2
3
4
5
...