Dopamine Signaling Leads to Loss of Polycomb Repression and Aberrant Gene Activation in Experimental Parkinsonism

@inproceedings{Sdersten2014DopamineSL,
  title={Dopamine Signaling Leads to Loss of Polycomb Repression and Aberrant Gene Activation in Experimental Parkinsonism},
  author={Erik S{\"o}dersten and Michael Feyder and Mads Lerdrup and Ana-Luisa Gomes and Hanna Kryh and Giada Spigolon and Jocelyne Caboche and Gilberto Fisone and Klaus Hansen and Filippo M Rijli},
  booktitle={PLoS genetics},
  year={2014}
}
Polycomb group (PcG) proteins bind to and repress genes in embryonic stem cells through lineage commitment to the terminal differentiated state. PcG repressed genes are commonly characterized by the presence of the epigenetic histone mark H3K27me3, catalyzed by the Polycomb repressive complex 2. Here, we present in vivo evidence for a previously unrecognized plasticity of PcG-repressed genes in terminally differentiated brain neurons of parkisonian mice. We show that acute administration of the… CONTINUE READING
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Ectopic Nurr1 in striatal neurons results in enhanced levodopa-induced dyskinesias in the 6-OHDA rat model of Parkinson’s disease [abstract

  • FP Manfredsson, NM Kanaan, JW Lipton, TJ Collier, SE Caryl
  • Mov Dis 29 Suppl
  • 2014
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