Dopamine Signaling Is Essential for Precise Rates of Locomotion by C. elegans

  title={Dopamine Signaling Is Essential for Precise Rates of Locomotion by C. elegans},
  author={Daniel T. Omura and Damon A. Clark and Aravinthan D. T. Samuel and H Robert Horvitz},
  booktitle={PloS one},
Dopamine is an important neuromodulator in both vertebrates and invertebrates. We have found that reduced dopamine signaling can cause a distinct abnormality in the behavior of the nematode C. elegans, which has only eight dopaminergic neurons. Using an automated particle-tracking system for the analysis of C. elegans locomotion, we observed that individual wild-type animals made small adjustments to their speed to maintain constant rates of locomotion. By contrast, individual mutant animals… CONTINUE READING
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