Dopamine Receptor Activation Is Required for Corticostriatal Spike-Timing-Dependent Plasticity

@article{Pawlak2008DopamineRA,
  title={Dopamine Receptor Activation Is Required for Corticostriatal Spike-Timing-Dependent Plasticity},
  author={V. Pawlak and Jason N. D. Kerr},
  journal={The Journal of Neuroscience},
  year={2008},
  volume={28},
  pages={2435 - 2446}
}
  • V. Pawlak, Jason N. D. Kerr
  • Published 2008
  • Biology, Medicine
  • The Journal of Neuroscience
  • Single action potentials (APs) backpropagate into the higher-order dendrites of striatal spiny projection neurons during cortically driven “up” states. The timing of these backpropagating APs relative to the arriving corticostriatal excitatory inputs determines changes in dendritic calcium concentration. The question arises to whether this spike-timing relative to cortical excitatory inputs can also induce synaptic plasticity at corticostriatal synapses. Here we show that timing of single… CONTINUE READING
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