Dopamine Partial Agonist Reverses Amphetamine Withdrawal in Rats

@article{Orsini2001DopaminePA,
  title={Dopamine Partial Agonist Reverses Amphetamine Withdrawal in Rats},
  author={Cristina Orsini and Geroge F. Koob and L. Pulvirenti},
  journal={Neuropsychopharmacology},
  year={2001},
  volume={25},
  pages={789-792}
}
Decreased motivation to work for a natural reward is a sign of amphetamine withdrawal and is thought to be associated with hypofunction of the mesolimbic dopamine system. During withdrawal from repeated amphetamine administration, rats showed reduced responding for a sweet solution in a progressive ratio schedule. Repeated systemic treatment with terguride (0.2 and 0.4 mg/kg, i.p.) twice daily during the first four days of amphetamine withdrawal reversed the decrease in responding for the sweet… CONTINUE READING
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