Dopamine Modulates Persistent Synaptic Activity and Enhances the Signal-to-Noise Ratio in the Prefrontal Cortex

@inproceedings{Kroener2009DopamineMP,
  title={Dopamine Modulates Persistent Synaptic Activity and Enhances the Signal-to-Noise Ratio in the Prefrontal Cortex},
  author={Sven Kroener and L Judson Chandler and Paul E M Phillips and Jeremy K. Seamans},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND The importance of dopamine (DA) for prefrontal cortical (PFC) cognitive functions is widely recognized, but its mechanisms of action remain controversial. DA is thought to increase signal gain in active networks according to an inverted U dose-response curve, and these effects may depend on both tonic and phasic release of DA from midbrain ventral tegmental area (VTA) neurons. METHODOLOGY/PRINCIPAL FINDINGS We used patch-clamp recordings in organotypic co-cultures of the PFC… CONTINUE READING

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