Dopamine-Induced Conformational Changes in Alpha-Synuclein

Abstract

BACKGROUND Oligomerization and aggregation of alpha-synuclein molecules play a major role in neuronal dysfunction and loss in Parkinson's disease [1]. However, alpha-synuclein oligomerization and aggregation have mostly been detected indirectly in cells using detergent extraction methods [2], [3], [4]. A number of in vitro studies showed that dopamine can… (More)
DOI: 10.1371/journal.pone.0006906

Topics

8 Figures and Tables

Cite this paper

@inproceedings{Outeiro2009DopamineInducedCC, title={Dopamine-Induced Conformational Changes in Alpha-Synuclein}, author={Tiago F Outeiro and Jochen Klucken and Kathryn K. Bercury and Julie E. Tetzlaff and Preeti Putcha and Lu{\'i}s M Oliveira and Alexandre Quintas and Pamela J McLean and Bradley T. Hyman}, booktitle={PloS one}, year={2009} }