Dopamine Dysregulation Syndrome

@article{Osullivan2009DopamineDS,
  title={Dopamine Dysregulation Syndrome},
  author={Sean S. O'sullivan and Andrew H Evans and Andrew John Lees},
  journal={CNS Drugs},
  year={2009},
  volume={23},
  pages={157-170}
}
Dopamine dysregulation syndrome (DDS) is a relatively recently described iatrogenic disturbance that may complicate long-term symptomatic therapy of Parkinson’s disease. Patients with DDS develop an addictive pattern of dopamine replacement therapy (DRT) use, administering doses in excess of those required to control their motor symptoms. The prevalence of DDS in patients attending specialist Parkinson’s disease centres is 3–4%. Amongst the behavioural disturbances associated with DDS are… 
Treating Parkinson's disease: Dopamine dysregulation syndrome and impulse control
Dopamine dysregulation syndrome (DDS) has emerged as a recognized complication of dopamine replacement therapy (DRT) in the treatment of Parkinson's disease. This syndrome is characterized by
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TLDR
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Dopamine agonists have a stereotyped withdrawal syndrome that can lead to profound disability in a subset of patients and Physicians should monitor patients closely when tapering these medications.
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A novel conceptual model is presented which combines biomedical and psychosocial factors in the genesis of ICDs in PD and it is argued that social and psychological factors also need to be considered to achieve a more complete understanding of the phenomenon.
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