Dopamine DA1 receptor agonist, fenoldopam, reverses glycine-induced hyperfiltration in rats.

  title={Dopamine DA1 receptor agonist, fenoldopam, reverses glycine-induced hyperfiltration in rats.},
  author={Yong Xian Wang and Miklos Gellai and David P. Brooks},
  journal={The American journal of physiology},
  volume={262 6 Pt 2},
Stimulation of dopamine DA1 receptors can prevent glomerular hyperfiltration in streptozotocin-induced diabetic rats. In the present study we have therefore investigated whether the DA1 agonist, fenoldopam, can prevent glycine-induced hyperfiltration. Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured by inulin and p-aminohippurate clearances in conscious chronically instrumented rats. Glycine (3.7 mg/min iv; n = 8) significantly increased GFR by 37% (from 1… Expand
Renal response to amino acid infusion in rats: effect of dopamine receptor antagonists and benserazide
It is suggested that endogenous dopamine could act as a mediator in the renal response to amino acid infusion in the rat, most likely by activation of DA2 receptors. Expand
Effect of dietary protein on the renal response to fenoldopam in diabetic rats.
The observation that the dopamine D1 receptor antagonist, SCH 23390, at a dose that abolished the renal vasodilator effects of fenoldopam, failed to alter renal hemodynamics in diabetic rats suggests that endogenous dopamine has little effect. Expand
A comparison between fenoldopam and low-dose dopamine in early renal dysfunction of critically ill patients*
In critically ill patients, a continuous infusion of fenoldopam at 0.1 &mgr;g/kg/min does not cause any clinically significant hemodynamic impairment and improves renal function compared with renal dose dopamine, and in the setting of acute early renal dysfunction, the attempt to reverse renal hypoperfusion with fen oldopam is more effective than with low-dose dopamine. Expand
Pathophysiological role of dopamine in the kidney: effects in diabetes mellitus and after contralateral nephrectomy.
In a long-term study lasting more than one year, streptozotocin-diabetic Wistar rats failed to develop overt nephropathy characterized by albuminuria and systemic hypertension, suggesting that endogenous DA plays a key role. Expand
Potential of dopamine A-1 agonists in the management of acute renal failure.
  • I. Singer, M. Epstein
  • Medicine
  • American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1998
Results of several studies in normal and hypertensive humans, and a few studies in animal models, are consistent with the notion that DA-1 agonists may be useful in preventing or treating ARF. Expand
Pathophysiological Role of Dopamine in the K Effects in Diabetes Mellitus and after Contralateral Nephrectomy idney :
Both insulin-dependent diabetes mellitus (IDDM) and unilateral nephectomy (UNX) are associated with an increase in the glomerular filtration rate. Glomerular hyperfiltration has been linked toExpand
Renal dopamine receptor function in hypertension.
There is convincing evidence that dopamine and dopamine receptors play an important role in regulation of renal function, suggesting that a defective dopamine receptor/signaling system may contribute to the development and maintenance of hypertension. Expand
Regional haemodynamic effects of dopamine and its prodrugs l‐dopa and gludopa in the rat and in the glycerol‐treated rat as a model for acute renal failure
The results indicate that gludopa is not renally selective at a pharmacodynamic level in normal, anaesthetized rats and contrary to this, a low dose ofgludopa does cause a renal selective vasodilatation and reduction of RR in rats with glycerol‐induced ARF. Expand
Pregnancy restores the renal vasodilator response to glycine in Dahl salt-sensitive rats.
Pregnancy resulted in significant increases in plasma volume, baseline glomerular filtration rate, and renal plasma flow and a significant decrease in renal vascular resistance. Expand
Dopamine D1 receptor (DRD1) genetic polymorphism: pleiotropic effects on heritable renal traits.
G-94A profiling may aid in predicting survival of renal function in patients with progressive renal disease because the -94A allele is common and may reduce glomerular capillary hydrostatic pressure. Expand