Dopamine DA1 receptor agonist, fenoldopam, reverses glycine-induced hyperfiltration in rats.

@article{Wang1992DopamineDR,
  title={Dopamine DA1 receptor agonist, fenoldopam, reverses glycine-induced hyperfiltration in rats.},
  author={Yong Xian Wang and Miklos Gellai and David P. Brooks},
  journal={The American journal of physiology},
  year={1992},
  volume={262 6 Pt 2},
  pages={
          F1055-60
        }
}
Stimulation of dopamine DA1 receptors can prevent glomerular hyperfiltration in streptozotocin-induced diabetic rats. In the present study we have therefore investigated whether the DA1 agonist, fenoldopam, can prevent glycine-induced hyperfiltration. Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured by inulin and p-aminohippurate clearances in conscious chronically instrumented rats. Glycine (3.7 mg/min iv; n = 8) significantly increased GFR by 37% (from 1… Expand
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