Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation.

@article{Bitner2006DopamineDR,
  title={Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation.},
  author={Robert Scott Bitner and Arthur L Nikkel and Stephani L. Otte and Brenda R Martino and Eve H Barlow and Pramila Bhatia and Andrew O. Stewart and Jorge D. Brioni and Michael W. Decker and Robert B. Moreland},
  journal={Neuropharmacology},
  year={2006},
  volume={50 5},
  pages={521-31}
}
The dopamine D4 receptor has been investigated for its potential role in several CNS disorders, notably schizophrenia and more recently, erectile dysfunction. Whereas studies have investigated dopamine D4 receptor-mediated signaling in vitro, there have been few, if any, attempts to identify dopamine D4 receptor signal transduction pathways in vivo. In the present studies, the selective dopamine D4 agonist PD168077 induces c-Fos expression and extracellular signal regulated kinase (ERK… CONTINUE READING

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