Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI

@article{MaronaLewicka2008DopamineDR,
  title={Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI},
  author={Danuta Marona-Lewicka and Benjamin R. Chemel and David E. Nichols},
  journal={Psychopharmacology},
  year={2008},
  volume={203},
  pages={265-277}
}
Lysergic acid diethylamide (LSD) differs from other types of hallucinogens in that it possesses direct dopaminergic effects. The exact nature of this component has not been elucidated. The present study sought to characterize the effects of several dopamine D4 agonists and antagonists on the discriminative stimulus effect of LSD at two pretreatment times and 2,5-dimethoxy-4-iodoamphetamine (DOI), a selective 5-HT2A/2C agonist. Male Sprague–Dawley rats were trained in a two-lever, fixed ratio… CONTINUE READING
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The “selective” 5-HT1A antagonist WAY100635 and its metabolite WAY-100634, are potent dopamine D4 receptor agonists

  • BR Chemel, BL Roth, B Armbruster, VJ Watts, D Marona-Lewicka, DE Nichols
  • ACNP, 45th Annual Meeting,
  • 2006
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