Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys

@article{Jentsch1999DopamineDR,
  title={Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys},
  author={James David Jentsch and JaneR . Taylor and D. Eugene Redmond Jr. and John D. Elsworth and Kenneth D. Youngren and Robert H. Roth},
  journal={Psychopharmacology},
  year={1999},
  volume={142},
  pages={78-84}
}
Abstract D4 dopamine receptors (DRs) are enriched in the primate prefrontal cortex, a brain region implicated in cognitive processes, and mesoprefrontal dopaminergic systems appear to be involved in modulating some cognitive functions of the prefrontal cortex. Despite anatomical localization of D4 DRs within the frontal cortex, the role of these receptors, specifically, in the regulation of cognition or behavior in primates is unknown. In these studies, we sought to learn whether specific… Expand
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