Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking

@article{Ebstein1996DopamineDR,
  title={Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking},
  author={Richard P. Ebstein and Olga Novick and Roberto Umansky and Beatrice Priel and Yamima Osher and Darren Blaine and Estelle R. Bennett and Lubov Nemanov and Miri Katz and Robert H. Belmaker},
  journal={Nature Genetics},
  year={1996},
  volume={12},
  pages={78-80}
}
Human personality traits which can be reliably measured by any of a number of rating scales, show a considerable heritable component1,2. The tridimensional personality questionnaire (TPQ) is one such instrument and was designed by Cloninger to measure four distinct domains of temperament — Novelty Seeking, Harm Avoidance, Reward Dependence and Persistence — that are hypothesized to be based on distinct neurochemical and genetic substrates. Cloninger proposed that individual variations in the… Expand
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    The present results do not provide evidence that the DRD4*7R allele contributes a common and relevant effect to alcohol-seeking behavior in the sample of alcoholics. Expand
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    • Psychology, Medicine
    • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
    • 2003
    TLDR
    It is concluded that the investigated DRD3 polymorphism does not have a major impact on personality in the investigated population. Expand
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    It is suggested that genetic association analyses can benefit by consideration of the shared functional and evolutionary attributes of the DRD4 2R and 7R alleles. Expand
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    TLDR
    The results suggest that minor 5-repeat allele is associated with high novelty-seeking scores in healthy Japanese subjects and the DRD4 VNTR polymorphism and TCI scores among the groups are compared. Expand
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    TLDR
    No significant associations were observed between novelty-seeking or positive emotional experience and these D4DR polymorphisms, which seems unlikely to represent measurement or genetic differences across studies, although environmental differences may be possible. Expand
    D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects.
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    Identification of a polymorphism in the promoter region of DRD4associated with the human novelty seeking personality trait
    TLDR
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