Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking

@article{Ebstein1996DopamineDR,
  title={Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking},
  author={Richard P. Ebstein and Olga Novick and Roberto Umansky and Beatrice Priel and Yamima Osher and Darren Blaine and Estelle R. Bennett and Lubov Nemanov and Miri Katz and Robert H. Belmaker},
  journal={Nature Genetics},
  year={1996},
  volume={12},
  pages={78-80}
}
Human personality traits which can be reliably measured by any of a number of rating scales, show a considerable heritable component1,2. The tridimensional personality questionnaire (TPQ) is one such instrument and was designed by Cloninger to measure four distinct domains of temperament — Novelty Seeking, Harm Avoidance, Reward Dependence and Persistence — that are hypothesized to be based on distinct neurochemical and genetic substrates. Cloninger proposed that individual variations in the… Expand

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