Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking

@article{Ebstein1996DopamineDR,
  title={Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking},
  author={Richard P. Ebstein and Olga Novick and Roberto Umansky and Beatrice Priel and Yamima Osher and Darren Blaine and Estelle R. Bennett and Lubov Nemanov and Miri Katz and Robert H. Belmaker},
  journal={Nature Genetics},
  year={1996},
  volume={12},
  pages={78-80}
}
Human personality traits which can be reliably measured by any of a number of rating scales, show a considerable heritable component1,2. The tridimensional personality questionnaire (TPQ) is one such instrument and was designed by Cloninger to measure four distinct domains of temperament — Novelty Seeking, Harm Avoidance, Reward Dependence and Persistence — that are hypothesized to be based on distinct neurochemical and genetic substrates. Cloninger proposed that individual variations in the… 
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1,455 Citations
Highly Influential Citations
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Methods Citations
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1,455 Citations

Dopamine D4 receptor exon III alleles and variation of novelty seeking in alcoholics.
TLDR
The present results do not provide evidence that the DRD4*7R allele contributes a common and relevant effect to alcohol-seeking behavior in the sample of alcoholics.
Dopamine D4 Receptor Exon III Polymorphism, Adverse Life Events and Personality Traits in a Nonclinical German Adult Sample
TLDR
The results indicate gender-specific influences of the DRD4 gene on human behavior and invite researchers to further investigate gene-environment correlations on personality traits.
Lack of association between dopamine D4 receptor gene and personality traits
TLDR
The dopamine D4 receptor gene is probably not of importance to the different personality dimensions as measured by the Karolinska Scales of Personality, but there was a tendency in the direction of the proposed association.
5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms.
TLDR
Three-way analysis of variance demonstrated that reward dependence and persistence scores were significantly reduced by the presence of the less common 5-HT2Cser polymorphism, and a significant interaction between the two dopamine receptor polymorphisms and the serotonin polymorphism on reward dependence.
Association study between dopamine D3 receptor gene variant and personality traits
  • E. Jönsson, E. Burgert, H. Bergman
  • Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2003
TLDR
It is concluded that the investigated DRD3 polymorphism does not have a major impact on personality in the investigated population.
The Dopamine D4 Receptor (DRD4) Exon 3 VNTR Contributes to Adaptive Personality Differences in an Italian Small Island Population
TLDR
It is suggested that emigration might have caused gene flow out the island that resulted in somewhat unpredictable changes in the frequencies of specific alleles, thus influencing islander personality traits.
Novelty seeking and the dopamine D4 receptor gene (DRD4) revisited in Asians: Haplotype characterization and relevance of the 2‐repeat allele
TLDR
It is suggested that genetic association analyses can benefit by consideration of the shared functional and evolutionary attributes of the DRD4 2R and 7R alleles.
Minor genetic variants of the dopamine D4 receptor (DRD4) polymorphism are associated with novelty seeking in healthy Japanese subjects
The dopamine D2 receptor gene TaqI A polymorphism is not associated with Novelty Seeking, Harm Avoidance and Reward Dependence in healthy subjects
Human novelty-seeking personality traits and dopamine D4 receptor polymorphisms: a twin and genetic association study.
TLDR
No significant associations were observed between novelty-seeking or positive emotional experience and these D4DR polymorphisms, which seems unlikely to represent measurement or genetic differences across studies, although environmental differences may be possible.
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