Dopamine D4 and D5 receptor gene variant effects on clozapine response in schizophrenia: Replication and exploration

@article{Hwang2012DopamineDA,
  title={Dopamine D4 and D5 receptor gene variant effects on clozapine response in schizophrenia: Replication and exploration},
  author={R Hwang and Arun Kumar Tiwari and Clement C H Zai and Daniel Felsky and James L Kennedy},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2012},
  volume={37},
  pages={62-75}
}
OBJECTIVES This study aimed to: 1) replicate previously reported associations between dopamine D4 receptor gene (DRD4) polymorphisms and antipsychotic (AP) response in a clozapine (CLZ) response sample; and 2) explore possible associations of polymorphisms across dopamine D5 receptor gene (DRD5) as well as other DRD4 regions. METHODS DRD4 exon III 48-bp, intron I (G)(n), and 120-bp repeat polymorphisms, and three DRD4 single nucleotide polymorphisms (SNPs); and DRD5 (CA/CT/GT)(n… CONTINUE READING

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