Dopamine D4 Receptor Gene Variation Moderates the Efficacy of Bupropion for Smoking Cessation

@inproceedings{Leventhal2012DopamineDR,
  title={Dopamine D4 Receptor Gene Variation Moderates the Efficacy of Bupropion for Smoking Cessation},
  author={Adam M. Leventhal and Sean P. David and Molly Brightman and David R. Strong and John E. McGeary and Richard A. Brown and Elizabeth E. Lloyd-Richardson and Marcus R Munaf{\`o} and George R. Uhl and Raymond Niaura},
  booktitle={The Pharmacogenomics Journal},
  year={2012}
}
Smokers (⩾10 cigarettes per day, N=331) of European ancestry taking part in a double-blind placebo-controlled randomized trial of 12 weeks of treatment with bupropion along with counseling for smoking cessation were genotyped for a variable number of tandem repeats polymorphism in exon III of the dopamine D4 receptor gene. Generalized estimating equations predicting point-prevalence abstinence at end of treatment and 2, 6 and 12 months after the end of treatment indicated that bupropion (vs… CONTINUE READING