Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells.

@article{Pedrosa2004DopamineDR,
  title={Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells.},
  author={Rui Pedrosa and Pedro P G Gomes and Chunyu Zeng and Ulrich Hopfer and Pedro A. Jos{\'e} and Patr{\'i}cio Soares-da-Silva},
  journal={British journal of pharmacology},
  year={2004},
  volume={142 8},
  pages={1343-53}
}
This study evaluated the response of the Na(+)/H(+) exchanger (NHE) to dopamine D(1)- and D(2)-like receptor stimulation in immortalized renal proximal tubular epithelial cells and freshly isolated renal proximal tubules from the spontaneously hypertensive rat (SHR) and their normotensive controls (Wistar Kyoto rats; WKY). Stimulation of D(1)-like receptors with SKF 38393 attenuated NHE activity in WKY cells (IC(50)=151 nM), but not in SHR cells. Stimulation of D(2)-like receptors with… CONTINUE READING