Dopamine D3 receptor ligands modulate the acquisition of morphine-conditioned place preference

@article{Francs2004DopamineDR,
  title={Dopamine D3 receptor ligands modulate the acquisition of morphine-conditioned place preference},
  author={Henriette Franc{\`e}s and Maria A. Smirnova and Ludovic Leriche and Pierre Sokoloff},
  journal={Psychopharmacology},
  year={2004},
  volume={175},
  pages={127-133}
}
RationaleThe dopamine D3 receptor has been shown to mediate conditioned effects of psychostimulants such as cocaine. The present work was aimed at determining whether drugs acting at D3 receptors alter acquisition of conditioned effects of opiates.MethodsWe have used the conditioned place preference (CPP) in mice, which permits the measurement of approach behaviour to environmental stimuli previously paired with drug effects. To assess the interaction of morphine and D3 receptor ligands during… 
Maternal deprivation and handling modify the effect of the dopamine D3 receptor agonist, BP 897 on morphine-conditioned place preference in rats
TLDR
It is shown that maternal deprivation and handling induced a prolonged morphine CPP, and different changes of D2/D3 receptor functioning revealed after morphine C PP.
Dopamine D3 Receptor Ligands Block Nicotine-Induced Conditioned Place Preferences through a Mechanism that does not Involve Discriminative-Stimulus or Antidepressant-Like Effects
TLDR
These findings support the use of D3R ligands as aids for smoking cessation and indicate that their effects would be selective for those rewarding or reinforcing effects of nicotine that contribute to the maintenance of tobacco-smoking behavior, without affecting subjective responses to nicotine or producing any antidepressant-like effects.
Morphine alters the locomotor responses to a D2/D3 dopamine receptor agonist differentially in adolescent and adult mice
TLDR
A potential explanation for the increased psychiatric disorder co-morbidities when drug use begins during adolescence is offered.
Dopamine D1 and D3 Receptor Polypharmacology in Cocaine Reward and Cocaine Seeking
TLDR
The aims of this dissertation were to evaluate the effects of the novel strategy of simultaneous treatments with a D3 receptor antagonist and D1 receptor partial agonist in animal models of drug addiction, including cue-induced reinstatement of cocaine seeking, cocaine conditioned place preference (CPP) and cocaine self-administration in rats.
Role of DRD3 in morphine-induced conditioned place preference using drd3-knockout mice
TLDR
The role of DRD3 in the expression of conditioned effects of morphine and the participation of the somatosensory cortex in these effects are confirmed.
The selective dopamine D3 receptor antagonist SB 277011-A, but not the partial agonist BP 897, blocks cue-induced reinstatement of nicotine-seeking.
TLDR
The role of DRD3 on reactivity to drug-associated stimuli is validated and it is suggested that theDRD3 antagonist, but perhaps not the DRD 3 partial agonist, could be used to prevent relapse in tobacco smokers.
Dopamine Receptor Subtypes in Reward and Relapse
TLDR
Down-regulation in dopamine receptors following chronic drug self-administration is discussed in reference to differential changes in dopamine receptor-mediated behavior, suggesting that better integration between biological and behavioral data is needed in future studies.
...
1
2
3
...

References

SHOWING 1-10 OF 65 REFERENCES
Dopamine D3 receptor ligands show place conditioning effect but do not influence cocaine-induced place preference
TLDR
Results suggest the D3-preferring agonists could affect the reward mechanisms of the brain, however, modulation of D3 receptor function does not appear to be a significant mechanism for modifying the place conditioning effect of cocaine.
Effects of dopaminergic D3‐receptor-preferring ligands on the acquisition of place conditioning in rats
TLDR
Results suggest that DA function in the structures involved in incentive learning could be controlled through inhibitory D3 (or 'D2-like') receptor-mediated processes.
Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist
TLDR
BP 897 inhibits cocaine-seeking behaviour that depends upon the presentation of drug-associated cues, without having any intrinsic, primary rewarding effects, which indicates that compounds like BP 897 could be used for reducing the drug craving and vulnerability to relapse that are elicited by drug- associated environmental stimuli.
Attenuation of Cue-Controlled Cocaine-Seeking by a Selective D3 Dopamine Receptor Antagonist SB-277011-A
TLDR
The results suggest that D3 dopamine receptors may be critically involved in cue-controlled drug-seeking behavior independently of any interaction with the reinforcing effects of cocaine itself, and may therefore provide a therapeutic target in the treatment of relapse to cocaine use induced by CSs.
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors
TLDR
The D2 receptor plays a crucial role in the motivational component of drug addiction, as mice lacking D2 receptors behaved the same as wild-type mice when food is used as reward.
A dopamine D3 receptor partial agonist blocks the expression of conditioned activity
TLDR
Results extend previous findings that BP 897 attenuates responding for cocaine-paired stimuli to amphetamine-PAired stimuli in a different paradigm and support the potential of BP 8 97 as a therapeutic agent for the prevention of drug seeking.
Dopamine D3 Receptor Antagonism Inhibits Cocaine-Seeking and Cocaine-Enhanced Brain Reward in Rats
TLDR
An important role for D3 receptors in mediating the addictive properties of cocaine is suggested and blockade of dopamine D3receptors may constitute a new and useful target for prospective pharmacotherapies for cocaine addiction.
Role of the dopamine D3 receptor in reactivity to cocaine‐associated cues in mice
TLDR
A modulation of reactivity to cocaine cues by the D3R is demonstrated, the expression of which is elevated in the NAc by the repeated association of drug effects with a particular context, through a BDNF‐dependent mechanism.
...
1
2
3
4
5
...