Dopamine D3 receptor-dependent changes in alpha6 GABAA subunit expression in striatum modulate anxiety-like behaviour: Responsiveness and tolerance to diazepam.

@article{Leggio2015DopamineDR,
  title={Dopamine D3 receptor-dependent changes in alpha6 GABAA subunit expression in striatum modulate anxiety-like behaviour: Responsiveness and tolerance to diazepam.},
  author={Gian Marco Leggio and Sebastiano Alfio Torrisi and Alessandro Castorina and Chiara Bianca Maria Platania and Agata Antonia Rita Impellizzeri and Annamaria Fidilio and Filippo Caraci and Claudio Bucolo and Filippo Drago and Salvatore Salomone},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2015},
  volume={25 9},
  pages={1427-36}
}
Increasing evidence indicates that central dopamine (DA) neurotransmission is involved in pathophysiology of anxiety, in particular the DA receptor subtype 3 (D3R). We previously reported that D3R null mice (D3R(-/-)) exhibit low baseline anxiety levels and that acutely administrated diazepam is more effective in D3R(-/-) than in wild type (WT) when tested in the elevated plus maze test (EPM). Here we tested the hypothesis that genetic deletion or pharmacological blockade of D3R affect GABAA… CONTINUE READING

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