Dopamine D3 receptor agonists produce similar decreases in body temperature and locomotor activity in D3 knock-out and wild-type mice

@article{Boulay1999DopamineDR,
  title={Dopamine D3 receptor agonists produce similar decreases in body temperature and locomotor activity in D3 knock-out and wild-type mice},
  author={Denis Boulay and Ronan Y Depoort{\`e}re and William Rost{\`e}ne and Ghislaine Perrault and David J. Sanger},
  journal={Neuropharmacology},
  year={1999},
  volume={38},
  pages={555-565}
}
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126 Citations
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126 Citations

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The role of dopamine D3 compared with D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats
TLDR
The facilitatory influence of a “high” dose of PD128,907 upon locomotion is mediated by postsynaptic D2 receptors and, possibly, countered by their D3 counterparts, while selective blockade of D2 but not of D3 receptors alone suppresses motor function.
Lack of functional D2 receptors prevents the effects of the D3-preferring agonist (+)-PD 128907 on dialysate dopamine levels
Behavioral effects of dopamine agonists and antagonists in MPTP-lesioned D3 receptor knockout mice
Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors
7-OH-DPAT and PD 128907 Selectively Activate the D3 Dopamine Receptor in a Novel Environment
TLDR
It is demonstrated that both compounds inhibit locomotion under novel environmental conditions in wild-type (WT) mice, but are without measurable behavioral effect under identical conditions in D3 receptor knockout mice, and conditions are established for the use of 7-OH-DPAT and PD 128907 as D3 receptors agonists in vivo.
Locomotor activity induced by MK-801 is enhanced in dopamine D3 receptor knockout mice but suppression by dopamine D3/D2 antagonists does not occur through the dopamine D3 receptor.
Role of Dopamine D2-like Receptors in Cocaine Self-Administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor Antagonists
TLDR
It is suggested that the D2 receptor is not necessary for cocaine self-administration, but this receptor subtype is involved in mechanisms that limit rates of high-dose cocaine self–administration.
Dopamine D3 receptor knock-out mice exhibit increased behavioral sensitivity to the anxiolytic drug diazepam
Effects of the D3 dopamine receptor antagonist, U99194A, on brain stimulation and d-amphetamine reward, motor activity, and c-fos expression in ad libitum fed and food-restricted rats
TLDR
Results indicate that U99194A has psychostimulant-like effects on motor activity and striatal c-fos expression that are dependent upon the D1 DA receptor, and seems consistent with the hypothesis that D3 antagonism enhances D1/D2 mediated signaling.
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References

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Hypothermia in mice: D2 dopamine receptor mediation and absence of spare receptors
Effects of the putative dopamine D3 receptor antagonist PNU 99194A on motor behavior and emotional reactivity in C57BL/6J mice.
Evidence for a role for dopamine D3 receptors in the effects of dopamine agonists on operant behaviour in rats.
TLDR
The results of this study are consistent with the view that D3 DA receptors may play an important role in mediating the behavioural effects of DA agonists and that these receptors have a presynaptic location.
Dopamine D3 Receptor Mutant Mice Exhibit Increased Behavioral Sensitivity to Concurrent Stimulation of D1 and D2 Receptors
Preferential involvement of D3 versus D2 dopamine receptors in the effects of dopamine receptor ligands on oral ethanol self-administration in rats
TLDR
Investigation of the relative involvement of D3 versus D2 dopamine receptors in the effects of dopamine ligands on the reinforcing action of ethanol found that reduction of dopamine transmission was associated with a decrease in ethanol-reinforced responding.
Alterations in Dopamine Release But Not Dopamine Autoreceptor Function in Dopamine D3 Receptor Mutant Mice
TLDR
The results suggest that the effects of PD 128907 on dopamine cell function reflect stimulation of D2 as opposed to D3 receptors, which may participate in postsynaptically activated short-loop feedback modulation of DA release.
Dopamine agonist-induced hypothermia and disruption of prepulse inhibition: evidence for a role of D3 receptors?
TLDR
The findings suggest that the hypothermia and PPI disruptions seen with some of these dopamine agonists may be mediated by central D3 receptors; however, only studies using more selective dopamine receptor ligands can definitively rule out effects at the D2 or D4 receptors.
Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: 1. Activation of postsynaptic D3 receptors mediates hypothermia, whereas blockade of D2 receptors elicits prolactin secretion and catalepsy.
TLDR
Data demonstrate that the novel naphthofurane, (+)-S 14297, is a selective ligand (antagonist) at dopamine D3 receptors and suggest that their activation mediates hypothermia in the rat.
A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice.
  • D. Accili, C. Fishburn, S. Fuchs
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1996
TLDR
The authors' findings indicate that D3 receptors play an inhibitory role in the control of certain behaviors, and this mutation is associated with hyperactivity in an exploratory test.
Investigations into the nature of a 7-OH-DPAT discriminative cue: comparison with D-amphetamine.
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