Dopamine D3 receptor agonists produce similar decreases in body temperature and locomotor activity in D3 knock-out and wild-type mice
@article{Boulay1999DopamineDR, title={Dopamine D3 receptor agonists produce similar decreases in body temperature and locomotor activity in D3 knock-out and wild-type mice}, author={Denis Boulay and Ronan Depoort{\`e}re and William Rost{\`e}ne and Ghislaine Perrault and David J. Sanger}, journal={Neuropharmacology}, year={1999}, volume={38}, pages={555-565} }
129 Citations
Dopamine D2 receptor knock-out mice are insensitive to the hypolocomotor and hypothermic effects of dopamine D2/D3 receptor agonists
- Biology, PsychologyNeuropharmacology
- 1999
The role of dopamine D3 compared with D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats
- Biology, PsychologyPsychopharmacology
- 2003
The facilitatory influence of a “high” dose of PD128,907 upon locomotion is mediated by postsynaptic D2 receptors and, possibly, countered by their D3 counterparts, while selective blockade of D2 but not of D3 receptors alone suppresses motor function.
Lack of functional D2 receptors prevents the effects of the D3-preferring agonist (+)-PD 128907 on dialysate dopamine levels
- BiologyNeuropharmacology
- 2005
Behavioral effects of dopamine agonists and antagonists in MPTP-lesioned D3 receptor knockout mice
- Biology, PsychologyPharmacology Biochemistry and Behavior
- 2003
Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors
- Biology, PsychologyNeuropharmacology
- 2003
7-OH-DPAT and PD 128907 Selectively Activate the D3 Dopamine Receptor in a Novel Environment
- Biology, PsychologyNeuropsychopharmacology
- 2003
It is demonstrated that both compounds inhibit locomotion under novel environmental conditions in wild-type (WT) mice, but are without measurable behavioral effect under identical conditions in D3 receptor knockout mice, and conditions are established for the use of 7-OH-DPAT and PD 128907 as D3 receptors agonists in vivo.
Locomotor activity induced by MK-801 is enhanced in dopamine D3 receptor knockout mice but suppression by dopamine D3/D2 antagonists does not occur through the dopamine D3 receptor.
- Biology, PsychologyEuropean journal of pharmacology
- 2010
Role of Dopamine D2-like Receptors in Cocaine Self-Administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor Antagonists
- Biology, PsychologyThe Journal of Neuroscience
- 2002
It is suggested that the D2 receptor is not necessary for cocaine self-administration, but this receptor subtype is involved in mechanisms that limit rates of high-dose cocaine self–administration.
Dopamine D3 receptor knock-out mice exhibit increased behavioral sensitivity to the anxiolytic drug diazepam
- Psychology, BiologyEuropean Neuropsychopharmacology
- 2011
Effects of the D3 dopamine receptor antagonist, U99194A, on brain stimulation and d-amphetamine reward, motor activity, and c-fos expression in ad libitum fed and food-restricted rats
- Biology, PsychologyPsychopharmacology
- 2002
Results indicate that U99194A has psychostimulant-like effects on motor activity and striatal c-fos expression that are dependent upon the D1 DA receptor, and seems consistent with the hypothesis that D3 antagonism enhances D1/D2 mediated signaling.
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