Dopamine D3 receptor agonists produce similar decreases in body temperature and locomotor activity in D3 knock-out and wild-type mice.

@article{Boulay1999DopamineDR,
  title={Dopamine D3 receptor agonists produce similar decreases in body temperature and locomotor activity in D3 knock-out and wild-type mice.},
  author={Denis Boulay and Ronan Depoort{\`e}re and William Rost{\`e}ne and Ghislaine Perrault and D. J. Sanger},
  journal={Neuropharmacology},
  year={1999},
  volume={38 4},
  pages={555-65}
}
The function of the dopamine (DA) D3 receptor, a member of the D2-like family, has not been firmly established. It has been reported that the potency of DA receptor agonists in producing hypothermia and hypolocomotion in rodents correlates more strongly with the in vitro affinity for, or potency (mitogenesis test) at the D3 than the D2 subtype. In order to investigate further the role of D3 receptors in hypothermia and hypolocomotion, we tested the effects of ip administration of three DA… CONTINUE READING

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