Dopamine D3 receptor Ser9Gly polymorphism and risperidone response.

  title={Dopamine D3 receptor Ser9Gly polymorphism and risperidone response.},
  author={H. Richard Lane and Shih-Kuan Hsu and Yi-Ching A. Liu and Yue-Cune Chang and Chiung-Hsien Huang and W Chang},
  journal={Journal of clinical psychopharmacology},
  volume={25 1},
Risperidone is an atypical antipsychotic agent with efficacy for both positive and negative symptoms of schizophrenia. Risperidone is a potent dopamine D3 antagonist and agonism at D3 sites induces behavioral suppression in rodents. We thus hypothesized that D3 antagonism may contribute to response to risperidone in negative symptoms. This study aimed to explore the influence of the Ser9Gly polymorphism of the dopamine D3 receptor (DRD3) gene on response to risperidone after controlling for… CONTINUE READING

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