Dopamine D3-preferring ligands act at synthesis modulating autoreceptors.

@article{Aretha1995DopamineDL,
  title={Dopamine D3-preferring ligands act at synthesis modulating autoreceptors.},
  author={Cheryl Wiley Aretha and Archana Sinha and Matthew Peter Galloway},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={274 2},
  pages={
          609-13
        }
}
Several compounds exist that demonstrate a binding preference for cloned dopamine D3 receptors vs. D2 receptors, including (+/-)7-OH DPAT, (+)-UH232 and (+)-AJ76. Inasmuch as recent evidence suggests that the dopamine D3 receptor may function as a dopamine autoreceptor, we have investigated the ability of these D3-preferring ligands to act at synthesis modulating dopamine autoreceptors using the gamma-butyro-lactone model in vivo to isolate the presynaptic effects of (+/-)7-OH DPAT, (+)-UH232… CONTINUE READING

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