Dopamine D3 Receptors Modulate the Ability of Win-Paired Cues to Increase Risky Choice in a Rat Gambling Task

@article{Barrus2016DopamineDR,
  title={Dopamine D3 Receptors Modulate the Ability of Win-Paired Cues to Increase Risky Choice in a Rat Gambling Task},
  author={Michael M Barrus and Catharine A. Winstanley},
  journal={The Journal of Neuroscience},
  year={2016},
  volume={36},
  pages={785 - 794}
}
Similar to other addiction disorders, the cues inherent in many gambling procedures are thought to play an important role in mediating their addictive nature. Animal models of gambling-related behavior, while capturing dimensions of economic decision making, have yet to address the impact that these salient cues may have in promoting maladaptive choice. Here, we determined whether adding win-associated audiovisual cues to a rat gambling task (rGT) would influence decision making. Thirty-two… 

Figures and Tables from this paper

Pharmacological evidence of a cholinergic contribution to elevated impulsivity and risky decision-making caused by adding win-paired cues to a rat gambling task
TLDR
These results contrast sharply from those obtained previously using the uncued rGT, and suggest that the deleterious effects of win-paired cues on decision-making and impulse control may result from elevated cholinergic tone.
Dopamine neurons gate the intersection of cocaine use, decision making, and impulsivity
TLDR
It is found that chronic dampening of DA signalling can have both protective and deleterious effects on addiction-relevant behaviours, depending on biological sex and dependent variable of interest.
Prior Exposure to Salient Win-Paired Cues in a Rat Gambling Task Increases Sensitivity to Cocaine Self-Administration and Suppresses Dopamine Efflux in Nucleus Accumbens: Support for the Reward Deficiency Hypothesis of Addiction
TLDR
It is shown that adding reward-concurrent cues to a rat analog of the IGT precipitates a hypodopaminergic state, characterized by blunted accumbal DA efflux and attenuated locomotor sensitization, which may contribute to the enhanced responsivity to uncertain rewards or the reinforcing effects of cocaine.
Pharmacological evidence that 5-HT2C receptor blockade selectively improves decision making when rewards are paired with audiovisual cues in a rat gambling task
TLDR
These findings demonstrate that the 5-HT2 receptor-mediated regulation of risky decision making and motor impulsivity can be pharmacologically dissociated and further show that the presence of highly salient reward-paired cues critically alters the neurochemical regulation of the choice process.
Win-Concurrent Sensory Cues Can Promote Riskier Choice
TLDR
Cues had risk-promoting effects on a risky choice task and independently increased task-related arousal as measured by pupil dilation, identifying a mechanism whereby cue reactivity could translate into maladaptive behavioral outcomes in people with addictions.
Relative insensitivity to time-out punishments induced by win-paired cues in a rat gambling task
TLDR
The emergence of risk-preferring choice on the rGT derives from a relative insensitivity to the cost of the time-out punishments, as opposed to a relative hypersensitivity to rewards, which is more likely to be induced in individual rats by the addition of salient audiovisual cues to rewards delivered on wins.
Gambling-like behavior in pigeons: ‘jackpot’ signals promote maladaptive risky choice
TLDR
An important role of an individual’s sensitivity to outcome-correlated cues in influencing risky choices that may moderate gambling behaviors in humans, particularly in casino and other gambling-specific environments is suggested.
Monoaminergic modulation of decision-making under risk of punishment in a rat model
TLDR
Decision-making under risk of punishment is selectively modulated by dopamine signaling, predominantly through D2 receptors, and drugs targeting serotonergic and noradrenergic signaling had few if any effects on choice behavior.
Cued Rat Gambling Task.
TLDR
The Cued rat Gambling Task (CrGT) is an operant behavioural task which pairs salient, audiovisual cues with the delivery of sucrose pellet rewards on complex schedules of reinforcement that involve both sugar pellet 'wins' and timeout penalty 'losses'.
Skewed by Cues? The Motivational Role of Audiovisual Stimuli in Modelling Substance Use and Gambling Disorders.
TLDR
Some of the comparatively simple paradigms in which reward-paired cues are known to modulate behaviour in rodents, such as sign-tracking, Pavlovian-to-instrumental transfer and conditioned reinforcement are reviewed.
...
...

References

SHOWING 1-10 OF 67 REFERENCES
Serotonergic and Dopaminergic Modulation of Gambling Behavior as Assessed Using a Novel Rat Gambling Task
TLDR
The data suggest that both serotonergic and dopaminergic agents can impair and improve gambling performance, and indicate that the rGT will be a useful tool to study the biological basis of gambling.
A Selective Role for Dopamine D4 Receptors in Modulating Reward Expectancy in a Rodent Slot Machine Task
Irrational Choice under Uncertainty Correlates with Lower Striatal D2/3 Receptor Binding in Rats
TLDR
The data suggest that the propensity for biased decision-making under uncertainty is influenced by striatal D2/3 receptor expression, and provide novel support for the hypothesis that susceptibility to chemical and behavioral addictions may share a common neurobiological basis.
Dopaminergic Modulation of Risk-Based Decision Making
TLDR
DA has a critical role in mediating risk-based decision making, with increased activation of D1 and D2 receptors biasing choice toward larger, probabilistic rewards, whereas D3 receptors appear to exert opposing effects on this form of decision making.
Chronic exposure to a gambling-like schedule of reward predictive stimuli can promote sensitization to amphetamine in rats
TLDR
Testing the hypothesis that chronic exposure to a gambling-like schedule of reward predictive stimuli can promote sensitization to amphetamine much like exposure to Amphetamine itself confirmed this hypothesis in rats.
Cue-Evoked Cocaine “Craving”: Role of Dopamine in the Accumbens Core
TLDR
There were large individual differences in the motivational properties of the cocaine cue, which were predicted by variation in the propensity to attribute incentive salience to a food cue, and this provided a promising preclinical approach for studying sources of individual variation in susceptibility to relapse due to conditioned craving.
Lesions of the Basolateral Amygdala and Orbitofrontal Cortex Differentially Affect Acquisition and Performance of a Rodent Gambling Task
TLDR
The maladaptive choice pattern observed on the IGT in patients with OFC lesions could therefore partially reflect a learning deficit, whereas amygdala damage may give rise to a more robust decision-making impairment.
Disadvantageous decision-making on a rodent gambling task is associated with increased motor impulsivity in a population of male rats.
TLDR
This work may represent the first demonstration of a clear association between choice and motor impulsivity in a nonclinical population and suggests that differences in impulsive behaviours between clinical and nonclinical populations may be ones of magnitude rather than ones of quality.
...
...