Dopamine D2 receptors in discrimination learning and spine enlargement

  title={Dopamine D2 receptors in discrimination learning and spine enlargement},
  author={Y. Iino and T. Sawada and K. Yamaguchi and Mio Tajiri and S. Ishii and H. Kasai and Sho Yagishita},
  • Y. Iino, T. Sawada, +4 authors Sho Yagishita
  • Published 2020
  • Chemistry, Medicine
  • Nature
  • Dopamine D2 receptors (D2Rs) are densely expressed in the striatum and have been linked to neuropsychiatric disorders such as schizophrenia 1 , 2 . High-affinity binding of dopamine suggests that D2Rs detect transient reductions in dopamine concentration (the dopamine dip) during punishment learning 3 – 5 . However, the nature and cellular basis of D2R-dependent behaviour are unclear. Here we show that tone reward conditioning induces marked stimulus generalization in a manner that depends on… CONTINUE READING
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