Dopamine D2 receptors and dopamine metabolism. Relationship between biochemical and behavioural effects of substituted benzamide drugs.

@article{Magnusson1986DopamineDR,
  title={Dopamine D2 receptors and dopamine metabolism. Relationship between biochemical and behavioural effects of substituted benzamide drugs.},
  author={Olle Magnusson and Christopher J Fowler and Christer K{\"o}hler and Sven Ove {\"O}gren Ogren},
  journal={Neuropharmacology},
  year={1986},
  volume={25 2},
  pages={187-97}
}
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride, raclopride, FLA 966(-), FLA 988(-), eticlopride and remoxipride as well as the "classical" dopamine antagonists, haloperidol and chlorpromazine, on the concentrations of dopamine, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the brain of the rat was investigated. All compounds increased the turnover of dopamine, as defined by increased concentrations of DOPAC and HVA (without change in the… CONTINUE READING

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The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
All compounds increased the turnover of dopamine , as defined by increased concentrations of DOPAC and HVA ( without change in the concentration of dopamine ) in the striatum in a dose - dependent manner .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
All compounds increased the turnover of dopamine , as defined by increased concentrations of DOPAC and HVA ( without change in the concentration of dopamine ) in the striatum in a dose - dependent manner .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
The effect of the substituted benzamide dopamine D2 receptor antagonists sulpiride , raclopride , FLA 966(- ) , FLA 988(- ) , eticlopride and remoxipride as well as the " classical " dopamine antagonists , haloperidol and chlorpromazine , on the concentrations of dopamine , dihydroxyphenylacetic acid ( DOPAC ) and homovanillic acid ( HVA ) in the brain of the rat was investigated .
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