Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.

@article{Yamaguchi1996DopamineDR,
  title={Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.},
  author={Hiroshi Yamaguchi and Atsu Aiba and Kei-ichiro Nakamura and Kazuki Nakao and Hiroshi Sakagami and Kiminobu Goto and H Kondo and Motoya Katsuki},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={1996},
  volume={1 2},
  pages={253-68}
}
BACKGROUND It has been suggested that the dopaminergic system is involved in the inhibitory control of secretion of pituitary hormones and in the regulation of motor function in the striatum. To elucidate the specific role of the dopamine D2 receptor (D2R) in the pituitary and brain, we generated D2R deficient (D2R mutant) mice using the gene targeting method. RESULTS Electrophysiological studies as well as ligand binding assays show no functional D2R in mutant mice. The D2R mutant mice… CONTINUE READING