Dopamine D2 receptor gene variants and quantitative measures of positive and negative symptom response following clozapine treatment

@article{Hwang2006DopamineDR,
  title={Dopamine D2 receptor gene variants and quantitative measures of positive and negative symptom response following clozapine treatment},
  author={Rudi Hwang and Takahiro Shinkai and Vincenzo Deluca and Fabio Macciardi and James L Kennedy},
  journal={European Neuropsychopharmacology},
  year={2006},
  volume={16},
  pages={248-259}
}
OBJECTIVE Explore relationships between 12 dopamine D2 gene variants and quantitative measures of positive and negative symptom response following clozapine treatment in two treatment refractory or intolerant populations (Caucasian and African-American). EXPERIMENTAL PROCEDURES Subjects included 97 Caucasian and 35 African-American DSM-III-R or DSM-IV schizophrenics and were genotyped by 5'-exonuclease fluorescence assays. Genotype, allele +/- and haplotype groups were compared on Brief… CONTINUE READING

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