Dopamine D2 receptor gene expression in human adenohypophysial adenomas

  title={Dopamine D2 receptor gene expression in human adenohypophysial adenomas},
  author={Lucia Stefaneanu and K{\'a}lm{\'a}n Kov{\'a}cs and Eva Horv{\'a}th and Michael Buchfelder and Rudolf Fahlbusch and Ioana Lancranjan},
The inhibitory effects of dopamine on adenohypophysial cells are mediated via dopamine subtype 2 receptor (D2R). Dopamine agonists inhibit hormone release and induce tumor shrinkage in most prolactin-secreting adenomas, whereas in other adenoma types such effects are sporadic. We investigated D2R gene expression by in situ hybridization (ISH) and immunocytochemistry in different types of pituitary adenomas. By ISH, a variable D2R signal was detected in 79 of 89 cases: 4 of 6 densely granulated… CONTINUE READING
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