Dopamine D2 receptor blocking effect of imipramine in the rat hippocampus

  title={Dopamine D2 receptor blocking effect of imipramine in the rat hippocampus},
  author={Antoni Śmiałowski},
  journal={Pharmacology Biochemistry and Behavior},
  • A. Śmiałowski
  • Published 1 May 1991
  • Biology, Psychology, Medicine, Chemistry
  • Pharmacology Biochemistry and Behavior

Effects of Dopamine on the Immature Neurons of the Adult Rat Piriform Cortex

A prominent role of dopamine, through D2r and PSA-NCAM, on the regulation of the final steps of development of immature neurons in the adult PCX is indicated.

Functions and mechanisms of interleukin 1 in the brain.

  • N. Rothwell
  • Biology, Psychology
    Trends in pharmacological sciences
  • 1991

Genetic and Pharmacological Analysis Controlling Egg Laying in C. elegans of Neurotransmitters

The results suggest that dominant egl-2 mutations activate an inhibitory dopaminergic pathway that can be blocked by tricyclics and D, antagonists, and find that these drugs stimulate egg laying in mutants lacking 5-HT or the HSN neurons, consistent with a target on the egg-laying muscles.

The Association Between Psychotropic Drug Use and Fertility Problems Among Male Subjects

The reviewed data suggest that these psychotropic medications can be associated with sexual function problems and negative effects on sperm parameters among male subjects, and Prospective, randomized clinical trials are necessary to elucidate the effects of psychotropic drugs on men’s sperm parameters and fertility indices per se.

Experimental confirmation of new drug-target interactions predicted by Drug Profile Matching.

DPM is an effective approach to reveal novel drug-target pairs that may result in repositioning these drugs and is demonstrated to be able to quantify the complete effect profiles of compounds via probability scores.

Experimental Con fi rmation of New Drug − Target Interactions

3 Laśzlo ́ Veǵner,†,# Ágnes Peragovics,†,# Laśzlo ́ Tombor,‡ Balaźs Jelinek, Paĺ Czobor,‡ Andreas Bender, 4 Zoltań Simon, and Andraś Maĺnaśi-Csizmadia*,†,§,∥ 5 †Department of Biochemistry, Institute

Toward a better understanding of inflammatory microvesicles in alcohol use disorder



Repeated Administration of Antidepressants Enhances Agonist Affinity for Mesolimbic D2‐Receptors

  • V. KlimekJ. Maj
  • Biology, Psychology
    The Journal of pharmacy and pharmacology
  • 1989
The data indicate that the enhanced responsiveness of the dopaminergic system in rats, observed after chronic treatment with antidepressants, may result from an increased affinity of agonists at D2‐receptors in the mesolimbic system.

Repeated treatment with imipramine or amitriptyline increases the locomotor response of rats to (+)‐amphetamine given into the nucleus accumbens

Effects of bilateral injections of (+)‐amphetamine into the nucleus accumbens were investigated in rats treated repeatedly with imipramine or amitriptyline, showing increased responsiveness of the mesolimbic dopaminergic system may be involved in the action of antidepressant drugs.

Effects of some antidepressant drugs on apomorphine concentration in the central nervous system of rats and apomorphine-induced stereotypy.

The presented results suggest that changes of APO behavioral effects induced by AD pretreatment are rather due to pharmacodynamic and not pharmacokinetic interaction.