Dopamine D2 receptor blocking effect of imipramine in the rat hippocampus

  title={Dopamine D2 receptor blocking effect of imipramine in the rat hippocampus},
  author={Antoni Śmiałowski},
  journal={Pharmacology Biochemistry and Behavior},
  • A. Śmiałowski
  • Published 1 May 1991
  • Medicine, Chemistry
  • Pharmacology Biochemistry and Behavior
The effect of dopamine receptor agonists on the spontaneous bioelectrical activity of CA1 layer neurons in the hippocampal slice preparation from the rat brain was studied. Two groups of rats were used: control and imipramine-pretreated ones (twice a day, for two weeks, 10 mg/kg PO). Dopamine and the selective D2 receptor agonist quinpirole induced an excitatory reaction; a similar effect was evoked by amphetamine, an indirect dopamine agonist. The effects of the three compounds were diminished… Expand
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