Dopamine D2 densities and the schizophrenic brain

@article{Zakzanis1998DopamineDD,
  title={Dopamine D2 densities and the schizophrenic brain},
  author={Konstantine K. Zakzanis and Kevin T. Hansen},
  journal={Schizophrenia Research},
  year={1998},
  volume={32},
  pages={201-206}
}

Dopamine receptors in the brains of schizophrenia patients: a meta‐analysis of the findings

It is concluded that a subgroup of schizophrenia patients manifests increased DA D 2 receptor density and decreased receptor affinity, and in the absence of medication, these changes may become more pronounced with age.

The primacy of cognition in schizophrenia.

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Deconstructing psychosis with human brain imaging.

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The dopamine dysfunction in schizophrenia revisited: new insights into topography and course.

Evidence from translational research suggests that dopaminergic excess may be present in the prodromal phase, and may by itself, be an early pathogenic condition, leading to irreversible cortical dysfunction.

Postmortem studies in schizophrenia

It can now be clearly concluded that there are structural cerebral abnormalities in schizophrenia that are intrinsic to the disorder.

Neurochemical dysfunction in treated and nontreated schizophrenia – a retrospective analysis of in vivo imaging studies

It may be hypothesized that schizophrenia initially is characterized by an impaired mechanism of D2 autoreceptor and heteroreceptor sensitization leading to sensitization instead of desensitization in response to increased levels of neostriatal DA.

Neurochemical brain imaging investigations of schizophrenia

Density of striatal D2 receptors in untreated first-episode psychosis: An I123-IBZM SPECT study

...

References

SHOWING 1-10 OF 31 REFERENCES

Central D2 Receptors and Negative Symptoms of Schizophrenia

The SD2R density index measured in vivo using 76Br-bromolisuride and PET correlated negatively with a psychomotor dimension of schizophrenia involving blunted affect and alogia, suggesting that the striatal dopamine system modulates symptoms such as flattened affect andAlogia.

Stereotypy, schizophrenia and dopamine D2 receptor binding in the basal ganglia

Investigation of the performance of antipsychotic-drug-free schizophrenic patients and healthy control subjects on a neuropsychological measure of stereotypy correlated this with in vivo striatal dopamine D2 receptor binding, as measured by 123I-iodobenzamide single photon emission tomography, to suggest a similar disturbance underlying the phenomenon in schizophrenia.

D2 Dopamine Receptor Binding in the Basal Ganglia of Antipsychotic-Free Schizophrenic Patients

The results suggest that alterations in striatal D2 receptor distribution and density do occur in schizophrenia, and possibly reflect wider disruptions in prefrontal-striatal-limbic circuits.

No D2 receptor increase in PET study of schizophrenia.

It is now possible to examine D2dopamine receptor binding in the brains of living human subjects by means of new brain-imaging techniques and radiolabeled receptor ligands and evidence of a slight increase in D2Dopamine receptors in a group of schizophrenic patients is reported.

Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.

Schizophrenia itself is associated with an increase in brain D2 dopamine receptor density, and the densities in the caudate nucleus were higher in both groups of patients than in the normal volunteers.

Bimodal distribution of dopamine receptor densities in brains of schizophrenics.

The dopamine hypothesis of schizophrenia was examined by measuring the density of dopamine receptors in the postmortem brains of 81 control subjects and 59 schizophrenics from four different countries, providing direct evidence for two distinct categories of schizophrenia.

Are Striatal Dopamine D4 Receptors Increased in Schizophrenia?

The increase in D2‐like receptor density in schizophrenia is due not to an increase in number of D4 sites in the disease, but to an up‐regulation of D2 or D3 receptors probably induced by chronic treatment with antipsychotic drugs.

Striatal D2 dopamine receptor characteristics in neuroleptic-naive schizophrenic patients studied with positron emission tomography.

There are no general changes in D2 dopamine receptor Bmax or Kd values in neuroleptic-naive schizophrenics, but there may be a subgroup of patients with aberrant striatal D 2 dopamine receptor characteristics in vivo.