Dopamine D2 Receptor Availability in Opiate-Dependent Subjects before and after Naloxone-Precipitated Withdrawal

@article{Wang1997DopamineDR,
  title={Dopamine D2 Receptor Availability in Opiate-Dependent Subjects before and after Naloxone-Precipitated Withdrawal},
  author={Gene-Jack Wang and Nora D. Volkow and Joanna S. Fowler and Jean Logan and Naji N. Abumrad and Robert J. Hitzemann and Naomi S Pappas and Kathy Pascani},
  journal={Neuropsychopharmacology},
  year={1997},
  volume={16},
  pages={174-182}
}
Dopamine may play a role in opiate withdrawal and dependence. We measured dopamine D2 receptor availability in 11 opiate-dependent subjects using PET and [11C]raclopride at baseline and during naloxone-precipitated withdrawal. Because [11C]raclopride is sensitive to endogenous dopamine, this strategy enabled us to test whether we could document in humans the DA reductions reported in animal models of opiate withdrawal. Results were compared with values from 11 controls, two of which also… CONTINUE READING

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