Dopamine D2-Like Receptor in the Nucleus Accumbens Is Involved in the Antinociceptive Effect of Nitrous Oxide

@article{Koyanagi2008DopamineDR,
  title={Dopamine D2-Like Receptor in the Nucleus Accumbens Is Involved in the Antinociceptive Effect of Nitrous Oxide},
  author={S. Koyanagi and S. Himukashi and K. Mukaida and T. Shichino and K. Fukuda},
  journal={Anesthesia \& Analgesia},
  year={2008},
  volume={106},
  pages={1904-1909}
}
BACKGROUND:The mechanism of the antinociceptive effects of nitrous oxide (N2O) has not been completely elucidated. On the other hand, numerous studies have indicated that mesolimbic dopaminergic neurons, which are thought to be involved in rewarding and reinforcement processes, play important roles in the supraspinal pain-suppression system. We hypothesized that the mesolimbic dopaminergic system is involved in the antinociceptive effect of N2O. METHODS:Adult male Fischer rats were used in this… Expand
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