Dopamine D2-D3 receptor heteromers: pharmacological properties and therapeutic significance.

  title={Dopamine D2-D3 receptor heteromers: pharmacological properties and therapeutic significance.},
  author={Roberto Maggio and Mark John Millan},
  journal={Current opinion in pharmacology},
  volume={10 1},
Heteromerization of dopamine receptors has been shown for both the D(1)/D(5) and D(2)/D(3)/D(4) receptor families, which couple positively and negatively, respectively, to adenylyl cyclase. The present article reviews data on dopamine heteromers formed by D(3), focusing in particular on associations with their D(2) counterparts. Certain antiparkinsonian agents, like the preferential and high efficacy D(3)>D(2) agonists, pramipexole, and ropinirole, show amplified potency at D(2)-D(3) heteromers… CONTINUE READING


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