Dopamine D2‐like sites in schizophrenia, but not in Alzheimer's, Huntington's, or control brains, for [3H]benzquinoline

@article{Seeman1997DopamineDS,
  title={Dopamine D2‐like sites in schizophrenia, but not in Alzheimer's, Huntington's, or control brains, for [3H]benzquinoline},
  author={Philip Seeman and H C Guan and Jos{\'e} N. Nobrega and D Jiwa and Rudolf Markstein and Joon Hyun Balk and Roberto Picetti and Emilliano Borrelli and Hubert H. M. Van Tol},
  journal={Synapse},
  year={1997},
  volume={25}
}
Although the basis of schizophrenia is not known, evidence indicates a possible overactivity of dopamine pathways. In order to detect any new dopamine receptor‐like sites which may be altered in schizophrenia, the present study used a new radioligand, a [3H]benzo[g]quinoline. The receptors were labelled by this ligand in the presence of other drugs to block the known dopamine D1, D2, D3, or D5 receptors (no D4‐selective ligands are available to block D4). Using this method, we found that… 

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    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
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