Dopamine D2‐like sites in schizophrenia, but not in Alzheimer's, Huntington's, or control brains, for [3H]benzquinoline

  title={Dopamine D2‐like sites in schizophrenia, but not in Alzheimer's, Huntington's, or control brains, for [3H]benzquinoline},
  author={Philip Seeman and H C Guan and Jos{\'e} N. Nobrega and D Jiwa and Rudolf Markstein and Joon Hyun Balk and Roberto Picetti and Emilliano Borrelli and Hubert H. M. Van Tol},
Although the basis of schizophrenia is not known, evidence indicates a possible overactivity of dopamine pathways. In order to detect any new dopamine receptor‐like sites which may be altered in schizophrenia, the present study used a new radioligand, a [3H]benzo[g]quinoline. The receptors were labelled by this ligand in the presence of other drugs to block the known dopamine D1, D2, D3, or D5 receptors (no D4‐selective ligands are available to block D4). Using this method, we found that… 

Novel D2-Like Dopamine Receptors in Schizophrenic Brain

Most traditional antipsychotic drugs have a high affinity for the D2 subtype of dopamine receptor, and there is a well-established relationship between typical daily dose of these drugs and affinity forThe D2 receptor, which has been interpreted to suggest a primary alteration in the D1 receptor in schizophrenia.

Imaging dopamine D4 receptors in the living primate brain: A positron emission tomography study using the novel D1/ D4 antagonist [11C]SDZ GLC 756

The widespread distribution of dopamine D4 receptors suggests a basic functional role of this receptor subtype in the modulation of cortical and subcortical neuronal activity.

Dopamine D2 and D4 receptor ligands: relation to antipsychotic action.

The dopamine D4 receptors and mechanisms of antipsychotic atypicality

  • A. H. WongH. V. Tol
  • Psychology, Medicine
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2003

Neurochemical alterations in schizophrenia affecting the putative receptor targets of atypical antipsychotics

What mechanisms make an antipsychotic atypical? A common view is that the different therapeutic and side-effect profile of atypical compared to typical antipsychotics is due to their high affinity

Cloning, expression, functional coupling and pharmacological characterization of the rat dopamine D4 receptor

Abstract. It has been difficult to observe functional coupling of the D4 receptor to second messenger systems and a robust functional assay system for this receptor is still lacking. In the present

The polymorphic nature of the human dopamine D4 receptor gene: A comparative analysis of known variants and a novel 27 bp deletion in the promoter region

Remarkably, the deleted region of the DRD4 gene contains consensus sequences of binding sites for several known transcription factors, suggesting that the different alleles may affect the transcriptional regulation of the gene.

On distributions of physiological and anatomical variables in pathological conditions: dopamine d2 receptors in schizophrenia and their occupancies after drug treatment

A factor which might determine whether there is a successful outcome in the treatment of schizophrenia with classical neuroleptics is in which tail of the assumed normal distribution, a patient's D2 receptor count falls.

Unraveling the Role of Dopamine Receptors In Vivo: Lessons from Knockout Mice

Major findings related to the contribution of each dopamine receptor in the control of physiological functions regulated by dopamine are summarized.

Towards understanding the schizophrenia code: An expanded convergent functional genomics approach

  • H. Le-NiculescuY. Balaraman A. Niculescu
  • Psychology, Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2007
A comprehensive convergent analysis of brain gene expression data from a relevant pharmacogenomic mouse model and human genetic linkage data and human postmortem brain data suggests that schizophrenia is primarily a disorder of brain functional and structural connectivity, with GABA neurotransmission playing a prominent role.