Dopamine D2(High) receptors moderately elevated by bifeprunox and aripiprazole.

@article{Seeman2008DopamineDR,
  title={Dopamine D2(High) receptors moderately elevated by bifeprunox and aripiprazole.},
  author={Philip Seeman},
  journal={Synapse},
  year={2008},
  volume={62 12},
  pages={902-8}
}
Because long-term antipsychotics elicit behavioral dopamine supersensitivity, the present study examined whether 7-9 days administration of partial dopamine D2 agonists with antipsychotic activity, bifeprunox and aripiprazole, could induce biochemical changes that suggest dopamine supersensitivity. In rats, behavioral dopamine supersensitivity is associated with increased dopamine D2(High) receptors in homogenized striata. In control rat striata, bifeprunox and aripiprazole had similar K(i… CONTINUE READING
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Bifeprunox: A novel atypical antipsychotic sharing dopamine D(2,3,4) and serotonin 5-HT(1A) receptor affinities

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