Dopamine D1A Receptor Regulation of Phospholipase C Isoform*

@article{Yu1996DopamineDR,
  title={Dopamine D1A Receptor Regulation of Phospholipase C Isoform*},
  author={P. Yu and G. Eisner and I. Yamaguchi and M. Mouradian and R. Felder and P. Jose},
  journal={The Journal of Biological Chemistry},
  year={1996},
  volume={271},
  pages={19503 - 19508}
}
In LTK− cells stably transfected with rat D1A receptor cDNA, fenoldopam, a D1 agonist, increased phosphatidylinositol 4,5-bisphosphate hydrolysis in a time-dependent manner. In the cytosol, phospholipase C (PLC) activity increased (50 ± 7%) in 30 s, returned to basal level at 4 h, and decreased below basal values by 24 h; in the membrane, PLC activity also increased (36 ± 13%) in 30 s, returned to basal level at 10 min, and decreased below basal value at 4 and 24 h. Fenoldopam also increased… Expand
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