Dopamine D1 receptor binding in the striatum of patients with obsessive-compulsive disorder.

@article{Olver2009DopamineDR,
  title={Dopamine D1 receptor binding in the striatum of patients with obsessive-compulsive disorder.},
  author={James S Olver and Graeme O'Keefe and Gareth R. Jones and Graham Dene Burrows and Henri Jacques Tochon-Danguy and Uwe Ackermann and Andrew Mark Scott and Trevor R. Norman},
  journal={Journal of affective disorders},
  year={2009},
  volume={114 1-3},
  pages={321-6}
}
BACKGROUND Obsessive-compulsive disorder (OCD) is a chronic anxiety disorder of unknown aetiology. Psychopharmacological studies have suggested a role for the neurotransmitter serotonin however further evidence for serotonin in the aetiology of OCD is conflicted. The authors used positron emission tomography (PET) to examine the binding of the dopamine D(1) receptor antagonist [(11)C]-SCH23390 to D(1) receptors in the striatum of drug-free OCD patients compared with healthy controls. METHODS… CONTINUE READING
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