Dopamine D1 receptor-agonist interactions: A mutagenesis and homology modeling study.

Abstract

The dopamine D1 receptor is a G protein-coupled receptor that regulates intracellular signaling via agonist activation. Although the number of solved GPCR X-ray structures has been steadily increasing, still no structure of the D1 receptor exists. We have used site-directed mutagenesis of 12 orthosteric vicinity residues of possible importance to G protein… (More)
DOI: 10.1016/j.bmcl.2015.03.079

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