Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations.

@article{Fu2007DopamineDR,
  title={Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations.},
  author={Wei Fu and Jianhua Shen and Xiaomin Luo and Weiliang Zhu and Jiagao Cheng and Kunqian Yu and James M. Briggs and Guozhang Jin and K. A. Chen and Hualiang Jiang},
  journal={Biophysical journal},
  year={2007},
  volume={93 5},
  pages={1431-41}
}
(-)-Stepholidine (SPD), an active ingredient of the Chinese herb Stephania, is the first compound found to have dual function as a dopamine receptor D1 agonist and D2 antagonist. Insights into dynamical behaviors of D1 and D2 receptors and their interaction modes with SPD are crucial in understanding the structural and functional characteristics of dopamine receptors. In this study a computational approach, integrating protein structure prediction, automated molecular docking, and molecular… CONTINUE READING